Cardiovascular Risk Factor, Lipemia
Conditions
Brief summary
This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.
Interventions
DIETARY_SUPPLEMENTGalactose
Co-ingestion of d-galactose with a high-fat meal
DIETARY_SUPPLEMENTGlucose
Co-ingestion of d-glucose with a high-fat meal
Sponsors
University of Bath
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Participants and the researchers performing biochemical analyses will be blinded to the intervention.
Intervention model description
Randomized, blinded crossover design.
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * 18 to 35 years old * Body mass index \<30 kg/m2
Exclusion criteria
* Female * Body mass index \>29.9 kg/m2 * Any history of metabolic disease * Allergies or intolerances to milk and/or cream
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial increase plasma triglyceride concentrations | 5 hours | Incremental area under the curve (iAUC) of plasma triglyceride concentrations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial subjective fullness ratings | 5 hours | Postprandial area under the curve of fullness ratings measured by visual analogue scales (0-100 mm) |
| Postprandial plasma glucose concentrations | 5 hours | Incremental area under the curve (iAUC) of plasma glucose concentrations |
| Postprandial plasma non-esterified fatty acid concentrations | 5 hours | Postprandial area under the curve of non-esterified fatty acid concentrations |
| Postprandial plasma lactate concentrations | 5 hours | Incremental area under the curve (iAUC) of plasma lactate concentrations |
| Postprandial subjective hunger ratings | 5 hours | Postprandial area under the curve of hunger ratings measured by visual analogue scales (0-100 mm) |
| Postprandial subjective satisfaction ratings | 5 hours | Postprandial area under the curve of satisfaction ratings measured by visual analogue scales (0-100 mm) |
| Postprandial prospective food consumption ratings | 5 hours | Postprandial area under the curve of prospective food consumption ratings measured by visual analogue scales (0-100 mm) |
| Postprandial overall appetite ratings | 5 hours | Postprandial area under the curve of overall appetite ratings measured by visual analogue scales (0-100 mm) |
| Postprandial plasma insulin concentrations | 5 hours | Incremental area under the curve (iAUC) of plasma insulin concentrations |
Countries
United Kingdom
Outcome results
None listed