Baro-reflex Sensitivity, Cerebral Blood Flow Regulation, Cerebral Oxygenation, Concentration Performance, EEG, Microstates, Heart Rate Variability, Oxygen Saturation
Conditions
Keywords
Hypoxia, Baro-reflex sensitivity, Low-intensity exercise, Hear rate variability, EEG, Concentration performance
Brief summary
The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different normobaric and hypobaric hypoxic conditions.
Detailed description
Subjects will bike at 1W/kg for 6 minutes at different simulated altitude level in the hypobaric chamber at the FAI in Dübendorf. Concentration performance also will be measured to better understand how hypobaric and hypoxia conditions may affect physiological responses, cerebral and cognitive functions.
Interventions
OTHERHypoxia
Subject will conduct low-intensity exercise on a bike in different hypoxic conditions.
Sponsors
University of Lausanne
Fliegerärztliches Institut
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Masking description
No drug and no arm are used for this study. This is a clinical study, because subjects are exposed to hypoxic conditions.
Intervention model description
Crossover randomized study
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Study Indication * Male and Female subjects from 18 years to 40 years of age * Healthy volunteer * Signed Informed Consent after being informed
Exclusion criteria
* Contraindications to the study intervention. * Define drugs, treatments or interventions not allowed during the study or for specific periods of time prior to the intervention, * Women who are pregnant or breast feeding, * Intention to become pregnant during the course of the study, * Known or suspected non-compliance, drug or alcohol abuse, * Previous problem with hypoxia or altitude exposure, * Known pathologies/diseases * Relevant medical disorders * Anemia or poor health * History of flight sickness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Baro-reflex sensitivity | 6 minutes per record. | To test the strength of relationship between RR interval and systolic blood pressure in human. Measurement before and after low intensity exercise in each condition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration performance | 4 minutes per test | Subjects will conduct a concentration test in each condition. |
| EEG microstates | 6 minutes per record | Microstates analysis to investigate how electrical cerebral activity is affected at rest in hypoxia and influenced by low intensity cycling exercise. |
| Heart rate variability (HRV) | 6 minutes per record | To investigate about stress (sympathetic and parasympathetic activation) in each condition tested. |
| Cerebral blood flow | 6 minutes per record. | Regulation of cerebral blood flow in hypoxia at rest and during low-intensity exercise. Measurement before, during and after low intensity exercise in each condition. 6 minutes recording per measurement. |
Countries
Switzerland
Outcome results
None listed