Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

Impact op Capillary Leak and Hypoalbuminemia on PK/PD of Ceftriaxone in Critically Ill Patients With Overwhelming Pneumonia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03438981

Enrollment

Registered

2018-02-20

Start date

2013-01-31

Completion date

2019-07-31

Last updated

2021-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Pharmacokinetics

Keywords

Pharmacokinetics, Ceftriaxone, critical illness, capillary leak, hypoalbuminemia

Brief summary

WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

Detailed description

First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid. Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed. Finally in a small subset of ECMO patients PK exposure will be explored.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Pneumonia * Admitted to an ICU ward * Treated with ceftriaxone

Exclusion criteria

* Pregnancy * DNR code 2-3 * Renal replacement therapy

Design outcomes

Primary

Measure	Time frame	Description
Risk factors for target non attainment	on day of sampling	risk factors will be assessed by comparing patients who attain target vs. those who don't

Countries

Belgium

Outcome results