Survey of Non-resuscitation Fluids in Septic Shock

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03438097

Acronym

SURF

Enrollment

200

Registered

2018-02-19

Start date

2018-03-01

Completion date

2018-08-15

Last updated

2018-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Keywords

Fluid therapy, Non-resuscitation fluids, Septic shock

Brief summary

The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.

Detailed description

Background: Several studies indicate that a large part of the fluid intake in intensive care patients consists of fluids that are given for indications other than volume expansion. However, the type of non-resuscitation fluids that hemodynamically unstable ICU patients receive has not been well characterized. Methods: A multicenter observational cohort study. Baseline data including, sex, age, physiological data at admission, source of sepsis, illness severity, and ICU and hospital mortality will be collected. Fluids administered during the first five days of ICU admission will be registered. Fluids used as vehicle to administer drugs will be regarded as non-resuscitation fluids and will be characterized in detail. All glucose solutions will be regarded as non-resuscitation fluids. Crystalloids delivered at a rate of \< 5 ml/kg/h will be considered as non-resuscitation fluids. Parenteral nutrition will be regarded as non-resuscitation fluids. Crystalloids delivered at a rate of ≥ 5 ml/kg/h will be considered to be resuscitation fluids. Blood products and colloids will be regarded as resuscitation fluids.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Septic shock per SEPSIS-3 criteria within 24 hrs of ICU admission * Informed consent from patient or next of kin if required by local ethical review Board

Exclusion criteria

• Lack of informed consent (see above)

Design outcomes

Primary

Measure	Time frame	Description
Type, indication and volume of fluids given to septic shock patients for other reasons than circulatory support.	First five days in ICU	Type of fluid is defined as either 0.9% normal saline, glucose, Ringers acetate/lactate, enteral nutrition, parenteral nutrition or sterile water. Indication is defined as vehicle, nutrition, maintenance or other. Volume will be reported in ml.

Countries

Canada, Sweden

Outcome results