Type 2 Diabetes Mellitus
Conditions
Keywords
Type 2 diabetes, Rutin, Vitamin C, oxidative stress, Insulin resistance, lipid profile
Brief summary
The objective of this study is to investigate the effect ofRutin and Vitamin C combination in comparison with vitamin C alone on the oxidative and antioxidative status , insulin resistance and lipid profile in type 2 diabetic patients.
Interventions
DIETARY_SUPPLEMENTRutin in combination with Vitamin C
Rutin and Vitamin C will be supplied as tablets containing 60 mg Rutin and 160 mg Vitamin C. The use of Rutin and Vitamin C will be under the trade name of RUTA C 60 ® manufactured by KAHIRA PHARM.& CHEM. IND. Company
DIETARY_SUPPLEMENTVitamin C
Vitamin C will be supplied as capsules containing500 mg of Vitamin C. The use of Vitamin C will be under the trade name of C-Retard ® manufactured by HIKMA Quality Company.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* • Patients' age 35 years or older having type 2 diabetes mellitus. * Patients taking oral diabetic medications (Sulfonylurea) not taking Insulin. * Able to understand and willing to sign a written informed consent document
Exclusion criteria
* • Pregnant and breast feeding females • use of vitamin supplements containing vitamin C or other antioxidants. * patients with renal or hepatic failure. * patients taking insulin as antidiabetic treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress marker (MDA) and antioxidant capacity (SOD) in diabetic patients | Two months | Effect of Rutin and vitamin C combination or vitamin C alone on oxidative stress marker (MDA) and on antioxidant capacity (SOD) in diabetic patients after 8 weeks of treatment. |
| Insulin resistance in diabetic patients . | Two months | Effect of Rutin and vitamin C combination or vitamin C alone on insulin resistance in diabetic patients before i and after treatment for 8 weeks . |
| Lipid profile in diabetic patients (TC,TG,HDL-c,LDL-c). | Two months | Impact of Rutin and vitamin C combination or vitamin C alone on lipid profile in diabetic patients (TC,TG,HDL-c,LDL-c). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life of diabetic patients and this will be evaluated by using Quality of Life Questionnaire (Short Form 36 questions (SF-36)) . | Two months | The effect of Rutin and vitamin C combination on quality of life of diabetic patients before and after treatment for 8 weeks and this will be evaluated by using Quality of Life Questionnaire (Short Form 36 questions (SF-36)) . |
Countries
Egypt
Outcome results
None listed