Obesity, Metabolically Benign
Conditions
Keywords
diet, metabolic syndrome, obese children
Brief summary
The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).
Detailed description
The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP). The investigators tested the hypothesis that long-term lifestyle changes and moderate weight loss would reduce the plasma concentrations of adipokines involved in inflammation, angiogenesis, and chemotaxis and would increase adiponectin concentrations. Material and methods: A prospective study was conducted over a period of 1 year, between January 2016 and December 2016, on 66 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timisoara. The patients diagnosed with MetS were put on diet and physical exercise for 3 months.
Sponsors
University of Medicine and Pharmacy Victor Babes Timisoara
Louis Turcanu Emergency Hospital for Children
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Inclusion criteria
* obese children (BMI\> 95th percentile)
Exclusion criteria
* obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Defining obesity in the pediatric population | Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile. | Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph. |
| Leptin changes in the obese children with metabolic syndrome | Leptin levels were measured on day 1 of admission and after three months. Normal range was considered < 24ng/ml. | Evaluating leptin in the obese group with metabolic syndrome after three months of diet and physical activity. |
| Adiponectin changes in the obese children with metabolic syndrome | Adiponectin levels were measured on day 1 of admittance and after three months in children aged between 4 and 18 years. Levels 4-26 mcg/ml were defined as normal values. | Evaluating adiponectin in the obese group with metabolic syndrome after three months of diet and physical activity. |
| hsCRP changes in the obese children with metabolic syndrome | hsCRP levels were measured on day 1 of admittance and after three months in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l. | Evaluating hsCRP in the obese group with metabolic syndrome after three months of diet and physical activity. |
Outcome results
None listed