Hepatopulmonary Syndrome
Conditions
Keywords
Hepatitis B, Chronic, Cirrhosis, Hepatopulmonary Syndrome
Brief summary
to investigate the prevalence of hepatopulmonary syndrome in cirrhosis patients caused by Hepatitis B in western China
Detailed description
Hepatopulmonary syndrome (HPS) occurs in approximately 4%-29% of cirrhotic patients and influences mortality. China has 100 million Hepatitis B virus (HBV) carriers and Chronic HBV infection is well-recognized risk factor for cirrhosis.But little is known about the prevalence of HPS in cirrhosis patients caused by HBV in western China. The aim of this study was to investigate the HPS incidence, and the signs, symptoms, arterial blood gas, and BMP9 in the serum of the patients.
Interventions
None listed
Sponsors
Southwest Hospital, China
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 18-80 years old; 2. American association of anesthesiologists(ASA) score: I-III; 3. Ability to comply with research programmes; 4. Voluntary participation in the study; 5. Has the history of HBV infection; 6. No primary cardiopulmonary disease (heart disease, emphysema, pneumonia, asthma, etc.)
Exclusion criteria
1. Severe heart, lung, kidney disease coexisted; 2. American association of anesthesiologists(ASA) score≥IV; forced expiratory volume at one second (FEV1) or forced vital capacity (FVC) \<70%, or FEV1 / FVC \<0.70; 3. Mental state could not cooperate 4. Absence of written informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxygen saturation | During the operation | oxygen saturation was examined by pulse oximetry |
| spider angioma | During the operation | spider angioma was examined by inspection |
| liver palms | During the operation | liver palms was examined by inspection |
| transthoracic contrast enhanced echocardiography (CEE) | During the operation | through the ultrasound to evaluate the imagine of cardiac cavity after intravenous injection of agitated saline |
| arterial blood gas | During the operation | arterial blood gas analysis was performed through the radial artery. |
| medical history | During the operation | The medical history was collected through consultation. |
| acropachy | During the operation | acropachy was examined by inspection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| micro ribonucleic acid 144 (miR144), micro ribonucleic acid 200 (miR200) in the patients with and without HPS | 4 to 6 months after the study completion | the content and expression of BMP9 were determined by polymerase chain reaction (PCR) |
| the content of bone morphogenetic protein (BMP9) in the patients with and without HPS | 4 to 6 months after the study completion | the content and expression of BMP9 were determined by immunohistochemistry. |
Countries
China
Contacts
Primary ContactYi Bin, PhD
Backup Contacttang xi, md
Outcome results
None listed