Mechanical Ventilation
Conditions
Keywords
Hyperoxemia, ventilator-associated, pneumonia, critical illness
Brief summary
The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence. * SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia. * Patients with VAP will be prospectively identified. * Patient characteristics and risk factors for VAP will be prospectively collected. * Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence. Patients with VAP will be compared with those with no VAP
Interventions
None listed
Sponsors
University Hospital, Lille
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients admitted to the ICU * Expected duration of mechanical ventilation \> 48h * Signed informed consent * Social insurance
Exclusion criteria
* Pregnancy or breast feeding * No informed consent * Hyperbaric oxygen treatment * Prisoners and patients under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAP occurrence | 28 days after ICU admission | hyperoxemia at ICU admission (PaO2 \>120 mmHg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| percentage of time spent with hyperoxemia during ICU stay, and the presence of acute lung injury | 28 days after ICU admission | the percentage of time spent with hyperoxemia during ICU stay will be calculated as mentioned above (outcome 2). This percentage will be compared between patient with ALI and those with no ALI |
| percentage of time spent with hyperoxemia during ICU stay | 28 days after ICU admission | hyperoxemia is defined as peripheral O2 saturation (SaO2)\>98%, SaO2 will be measured every 30 seconds, and the percentage of time spent with hyperoxemia will be calculated per day. |
| relationship between hyperoxemia at ICU admission and the presence of acute lung injury (ALI) | 28 days after ICU admission | the presence of hyperoxemia at ICU admission will be determined using blood gazes (arterial PaO2\>120 mmHg). The percentage of patients with hyperoxemia will be compared between patients with Ali, and those with no ALI |
Countries
France
Outcome results
None listed