Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

To Investigate the Prognostic Value of Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03433105

Enrollment

157

Registered

2018-02-14

Start date

2018-01-23

Completion date

2020-08-14

Last updated

2020-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Weaning

Keywords

oxygen uptake, prolonged mechanical ventilation, weaning

Brief summary

1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant. Otherwise, if the work load was above the patient's AT, the oxygen uptake will increase. 1. Patient: who have tracheostomy tubes and with prolonged mechanical ventilation 2. Measurement: oxygen uptake(V̇O2) and respiratory mechanics during the spontaneous breathing trials 3. Outcome: Correlation between the oxygen uptake(V̇O2) and the weaning outcome 2.Specific aims: 1. to investigate the prognostic value of oxygen uptake in weaning patients from prolonged mechanical ventilation 2. Subgroup analysis may suggest which weaning protocol potentially benefit the most for each population group (cardiovascular disease, chronic pulmonary disease, neuromuscular disease, cerebrovascular disease)

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 100 Years

Healthy volunteers

Inclusion criteria

1. Inclusion criteria: Adult \>20 y/o Total duration of mechanical ventilation ≥ 10 days Received tracheostomy Defervescence Meeting the criteria of weaning phase (see supplementary protocols) 2.

Exclusion criteria

FiO2 \>50 % Unstable hemodynamics Fever with active infection No spontaneous respiratory drive Dynamic airway collapse

Design outcomes

Primary

Measure	Time frame	Description
Measurement of oxygen uptake (V̇O2)	up to 12 hours during the spontaneous breathing trial	oxygen uptake during the spontaneous breathing trial

Countries

Taiwan

Outcome results