Salivary Antioxidant Capacity Before and After Complete Dental Rehabilitation

Salivary Antioxidant Capacity of Children With Severe Early Childhood Caries (S-ECC) Before and After Complete Dental Rehabilitation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03432728

Enrollment

Registered

2018-02-14

Start date

2016-01-25

Completion date

2017-12-31

Last updated

2018-02-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries in Children

Keywords

Antioxidant Capacity

Brief summary

Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and sex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Detailed description

Background: The association of total salivary antioxidant capacity (TAC) to severe early childhood caries (S-ECC) has been studied in the past. It is not clear if TAC is an indicator of the inflammatory response to the lesion or a marker of the disease. Aim: This study aimed to measure the salivary TAC levels in children with early childhood caries before and after dental treatment and compare the results to caries free children. Methodology: Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and gendersex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Interventions

PROCEDUREDental rehabilitation under general anesthesia

Dental treatment of all teeth affected by dental caries in a single visit under general anesthesia

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Months to 72 Months

Healthy volunteers

Yes

Inclusion criteria

* Medically fit children * Age below 71 months * Test group - to be diagnosed with severe ECC * Control group - to be caries free

Design outcomes

Primary

Measure	Time frame	Description
Change in TAC after one week	One week	Change in Total Salivary Antioxidant Capacity of children from baseline to one week after treatment
Change in TAC after Three months	Three months	Change in Total Salivary Antioxidant Capacity of children from baseline to three months after treatment

Countries

Saudi Arabia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026