Coronary Artery Bypass Surgery, Myocardial Ischemia
Conditions
Brief summary
Objective of the study is to clarify humanin-like peptide concentration in myocard tissue and in blood and to study if its concentration level is related to early complication occurrence and frequency after cardiac operation. Hypothesis of the study is that previously described elements are related to each other.
Detailed description
Data collection: Historical medical and preoperative data, operation data (type of operation performed and its details), detailed postoperative course (occurrence of complications). Specimen collection: * Tissue sample is taken during the operation from the right atrial appendage of the heart and the sample is frozen at -80 C. * Blood samples are taken just before the operation, one hour after aortic cross-clamp removal and the next morning after the operation. Samples are processed and blood plasma is frozen at -80 C.
Interventions
None listed
Sponsors
Tartu University Hospital
North Estonia Medical Centre
University of Tartu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age at least 18 years * Ischemic heart disease in medical history * Planned on-pump coronary artery bypass graft (CABG) operation * Signed informed consent by patient
Exclusion criteria
* Age \<18 years * Planned isolate valve or aortic operation * Patient is in another study with an intervention * Absence of signed informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 30 days | 30-day all-cause mortality |
| Major complications: myocardial infarction. | 30 days | Diagnosed myocardial infarction. |
| Major complications: acute kidney injury. | 30 days | Diagnosed acute kidney failure (KDIGO stage). |
| Major complications: stroke. | 30 days | Diagnosed stroke. |
Countries
Estonia
Outcome results
None listed