Acute Kidney Injury
Conditions
Keywords
Acute Kidney Injury, midodrine, intensive care unit
Brief summary
The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.
Detailed description
In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.
Interventions
DRUGmidodrine
oral midodrine tablets 5 mg
DRUGPlacebo
Sponsors
New Jeddah Clinic Hospital
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU patients * acute kidney injury * age above 18 years * documented hypotension during dialysis
Exclusion criteria
* packed red blood cells transfusion * intravenous inotropes * alteration of blood pressure medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of hypotensive episodes | 30 days from start of hemodialysis | Number of hypotensive episodes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mean systolic blood pressure | 30 days from start of hemodialysis | compare mean systolic blood pressure between the two arms |
| mean diastolic blood pressure | 30 days from start of hemodialysis | compare mean diastolic blood pressure between the two arms |
| Mortality in each arm | 30 days from start of hemodialysis | Number of dead patients in each arm |
Outcome results
None listed