Anesthesia, Intravenous Fluid, Blood Pressure
Conditions
Brief summary
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration. It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.
Detailed description
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration. It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.
Interventions
Lung Recruitment Maneuver by Anesthesiologist
OTHERFluid Administration
Administration of IV Fluid by Anesthesiologist
Sponsors
Masimo Corporation
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Inclusion criteria
* 0 to \< 18 years old * Undergoing surgery at Boston Children's Hospital under general anesthesia * mechanically ventilated with an endotracheal tube * Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure
Exclusion criteria
* Prematurity * Low birth weight * Congenital heart disease * Left or right ventricular dysfunction * Cardiac arrhythmia * Pulmonary hypertension * Preoperative parenchymal or interstitial lung disease * Intracranial hypertension * Poor transthoracic acoustic window * Obesity * Allergy to ultrasound transmission gel * Need for single lung ventilation * Systemic hypertension on antihypertensive medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in stroke volume | immediately before and after each intervention | Evaluate Lung Recruitment Maneuver as a means to predict fluid responsiveness in mechanically ventilated pediatric patients in the operating room. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in arterial compliance effect on Systolic Pressure Variation (mmHg) | immediately before and after each intervention | Evaluate the effect of arterial stiffness on Systolic Pressure Variation (mmHg) in mechanically ventilated pediatric patients in the operating room. |
| Change in arterial compliance effect on Pulse Pressure Variation (%) | immediately before and after each intervention | Evaluate the effect of arterial stiffness on Pulse Pressure Variation (%) in mechanically ventilated pediatric patients in the operating room. |
| Change in arterial compliance effect on Plethysmographic Variability Index (%) | immediately before and after each intervention | Evaluate the effect of arterial stiffness on Plethysmographic Variability Index (%) in mechanically ventilated pediatric patients in the operating room. |
Countries
United States
Contacts
Primary ContactViviane Nasr, MD
Outcome results
None listed