Hepatocellular Carcinoma
Conditions
Brief summary
¹¹C-choline positron emission tomography/computed tomography (PET/CT) has been used in patients with some types of solid cancers, but few data are available in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to analyze the prognostic value of metabolic imaging data by using ¹¹C-choline PET/CT in patients with HCC before hepatectomy.
Detailed description
Our prospectively maintained liver unit database was queried for patients with HCC preoperatively staged with ¹¹C-choline PET/CT. This metabolic imaging modality was performed in addition to standard abdominal CT or magnetic resonance imaging. Several PET/CT parameters were recorded and analyzed. Univariate and multivariate analyses were performed to identify whether those PET/CT parameters could be predictors of overall survival (OS) and disease-free survival (DFS) of HCC patients.
Interventions
PROCEDUREHepatectomy
Surgery of the liver: removal of a given part of the liver affected by hepatocellular carcinoma
Sponsors
Humanitas Clinical and Research Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any patient with HCC candidate to surgical resection preoperatively staged with ¹¹C-choline PET/CT
Exclusion criteria
* R2 resection; * Intraoperative use of RFA/MWI * Postoperative death (90-days)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of PET/CT parameters that can be predictors of survival | From date of surgery until the date of first documented progression or date of death from any cause, whichever came first assessed up to 72 months | Identification of specific PET/CT parameters that can be used as independent predictors of overall and/or disease-free survival |
Outcome results
None listed