Antibody-mediated Rejection
Conditions
Brief summary
In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria and Banff-classification. Twenty-five patients will be selected each in the therapy-responder and non-responder group. Their stored Formalin Fixed Paraffin Embedded (FFPE) biopsies will be (re)-classified according to the most recent Banff classification. Using Nanostring Technology the gene transcription of therapy-responders versus non-responders will be analyzed and compared to serological and clinical parameters.
Interventions
DIAGNOSTIC_TESTTranscriptome Analysis
Transcriptome Analysis of Formalin Fixed Paraffin Embedded biopsies
Sponsors
Thomas Mueller
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Kidney transplant patients at the University Hospital of Zurich between 01.01.2008 - 31.12.2016 with histologically suspected or confirmed ABMR * Written consent for further use of data for research purposes
Exclusion criteria
* Age at transplantation \< 18 years * Combined organ transplantation (incl. Kidney-Pancreas, Kidney-Liver, Kidney-Heart) * Incomplete laboratory and/or clinical data * Recurrence of the initial disease * Insufficient Biopsy Material for NanoString Analysis * Documented refusal of further data analysis for research purpose
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcriptome | 02.15.2018-03.01.2018 | mRNA |
Contacts
Primary ContactThomas F. Mueller, Prof.
Backup ContactOnur Sazpinar
Outcome results
None listed