Binge Eating, Purging (Eating Disorders)
Conditions
Brief summary
The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.
Interventions
OTHERMagnetic resonance imaging
We will conduct MRI and fMRI brain scans to compare brain function between groups.
Sponsors
Stanford University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
14 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Female * Ages 14-18 * with or without current binge eating and/or purging behaviors
Exclusion criteria
We exclude patients of clinically significant low weight (\<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain activity during emotion conflict | Baseline | Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict. |
| Brain activity during emotion regulation | Baseline | Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses. |
| Brain activity during cognitive control and emotion response | Baseline | Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavioral performance on emotion conflict task | Baseline | Response times will be used as behavioral measure on the emotion conflict task |
| Behavioral performance on emotion regulation task | Baseline | Emotion ratings will be used as behavioral measure on the emotion regulation task |
| Behavioral performance on cognitive control and emotion regulation task | Baseline | Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task |
Countries
United States
Outcome results
None listed