Healthy
Conditions
Keywords
intranasal oxytocin, functional brain network, multiple tasks, resting state
Brief summary
To investigate whether and how intranasal oxytocin of 8IU treatment will alter the topology of functional brain network in resting-state and multiple tasks in healthy males.
Detailed description
In a randomized, double-blind, cross-over, placebo controlled design, healthy male volunteers receive intranasal oxytocin or placebo prior to functional magnetic resonance imaging.Subjects will then go through a decision making task, a emotion judgement task and an eight-minute resting-state scan in MRI scanner to investigate whether and how intranasal oxytocin alter the topology of functional brain network in resting-state and multiple tasks in healthy males. State anxiety and mood are measured before and after experiment as covariates to be controlled.
Interventions
DRUGOxytocin
intranasally administrated
DRUGPlacebo
intranasally administrated
Sponsors
Beijing Normal University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Intervention model description
The study utilized a randomized, double-blind, PBO controlled, within-subject design, in which each participant was tested under two acute treatment conditions separated by at least 1 wk wash-out period.
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects without past or current psychiatric or neurological disorders
Exclusion criteria
* with MRI Contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional network organization alterations in brain under resting state fMRI after drug administration | 70~85 minutes after drug administration | Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional network organization in brain under eight minutes resting state will be detected and compared between oxytocin and placebo group. |
| Behavior,brain activities and representation patterns in the emotional judgement task after drug administration | 60~75 minutes after drug administration | Friend or Foe Task is used to measure the verbal versus nonverbal emotional judgement of subjects. Both the response of subjects and the brain activity are recorded in the task. How oxytocin influences the relationship between subjects' behavior and representation pattern of emotional judgement will be investigated through RSA(representation similarity analysis) of brain pattern. |
| Behavior, dynamics brain activities and networks in the model-based decision making task after drug administration | 35~60 minutes after drug administration | Two-Stage Decision Making Task is used to measure the model-based and model-free decision making process of subjects. The degree of model-based will be calculated by Computational modelling of Subjects' decision making process, and entering as modulation parameter in the OT effect on dynamic brain seed-based and network-based connectivity pattern. |
| Relationship of functional network organization in brain across resting state and task-based fMRI after drug administration | 60~85 minutes after drug administration | The functional brain activity in resting state, emotional judgement and decision making task will be compared. Both the functional segregation and integration will be measured using graph theory and network connectivity analysis to discover the OT effect on brain network organization across multiple cognitive states. |
Countries
China
Outcome results
None listed