Transurethral Resection of Prostate Syndrome
Conditions
Keywords
TURP, hypertonic saline, TURP syndrome, hyponatraemia
Brief summary
This study is designed to investigate the usage & effects of prophylactic HS preloading, with two different concentrations, to combat the expected dilutional hyponatremia induced by irrigating fluid absorption and to prevent the occurrence of TURP syndrome with its potential complications
Detailed description
The study will be conducted on 60 patients ASA class I - III BPH patients, candidates for TURP surgery using monopolar electronic resectoscope. Eligible patients will be allocated into one of three study groups (n=20 in each). Group A patients will receive NaCl 3% HS at a dose of 4 ml/kg/hr; Group B patients will receive NaCl 3% HS at a dose of 2 ml/kg/hr; while Group C patients will receive NaCl 0.9% Normal Saline(NS) at a dose of 6 ml/kg/hr. All intra-venous infusions will be started 30 minutes before the subarachnoid block, and continued all through the procedure at the same specific rate for each infusion. Vital signs \[mean BP, HR, CVP & oxygen saturation (spO2)\] will be recorded. Plasma electrolytes (sodium, potassium, chloride)and serum osmolality (mOsm) will be measured. Incidence of TUR syndrome, need for ICU admission, post-operative ventilation and total hospital stay will be noted.
Interventions
DRUGNaCl 3% HS
Hypertonic saline 3% is a type of crystalloid solution with osmolarity higher than that of plasma.
DRUGNaCl 0.9% NS
Normal saline 0.9% is a type of crystalloid solution with osmolarity similar to that of plasma.
Sponsors
Ahmed Mohamed ELbadawy
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ASA class I - III BPH patients
Exclusion criteria
* Patients having any condition contra-indicating regional anesthesia e.g impaired coagulation. * Electrolyte imbalance, * Uncontrolled hypertension, * Congestive heart failure or being allergic to local anesthetics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum sodium level measured in mEq/L | 72 hours | Hyponatremia was defined as a serum sodium \< 130 mEq/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of TURP syndrome | 72 hours | Occurring TURP syndrome manifestations |
| Need for ICU admission | 72 hours | For cardio-pulmonary support(vasopressor,mechanical ventilation), neurological monitoring |
Countries
Egypt
Outcome results
None listed