in Vitro Fertilization
Conditions
Brief summary
The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.
Interventions
OTHERHCG
250 μg/0.5ml choriogonadotropine alpha, Ovitrelle, Merck Serono
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is aged between 18 and 40 * Patient has regular cycles and classified as 'easy' for transfer of a frozen embryo at blastocyste stage (vitrification day 5)
Exclusion criteria
* The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Patient using donated oocytes * Necessity of pre-implantation diagnosis * Patients with stage 3 or 4 endometriosis or adenomyosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy rate after transfer of frozen embryos at day 14 between groups | Day 14 | Yes/no; Blood ßHCG \> 100UI/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Miscarriage rate within first 12 weeks | Week 12 | Yes/no; ultrasound |
| Live birth | At delivery, maximum week 42 | Yes/no |
| Pregnancy term | At delivery, maximum week 42 | Weeks |
| Pregnancy rate at week 12 | Week 12 | Yes/no; ultrasound |
| Cancellation of transfer due to premature ovulation (progesterone >3ng/ml and/or Luteinizing hormone > 3-fold base level) | Day 0 | Yes/no |
| Number of visits for endometrial preparation until attaining LH peak | Day 0 | Number of visits |
| Birth weight | At delivery, maximum week 42 | Kg |
Countries
France
Outcome results
None listed