Overweight
Conditions
Keywords
Glucagon-like Peptide-1, Glucose, Gastric bypass, Bariatric surgery, Obesity, Diabetes
Brief summary
To investigate the impact of canagliflozin on secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1) in gastric bypass operated patients.
Detailed description
Glucose is a potent stimulus for GLP-1 secretion after gastric bypass surgery and the SGLT-1 transporter appears to be crucial for this response. The study will investigate the effects of SGLT-1/SGLT-2 inhibition (by canagliflozin) on secretion of GLP-1 and other gut hormones after gastric bypass surgery.
Interventions
DIETARY_SUPPLEMENTGlucose
Ingestion of glucose (50 g) dissolved in 200 ml water.
DIETARY_SUPPLEMENTGlucose + Canagliflozin
Ingestion of glucose (50 g) dissolved in 200 ml water combined with the SGLT-1/SGLT-2 inhibitor canagliflozin.
Sponsors
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
10 gastric bypass patients
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
•Uncomplicated gastric bypass surgery performed minimum 12 months prior to study
Exclusion criteria
* Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery * Pregnancy or breastfeeding * Haemoglobin levels below 6,5 mM
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in GLP-1 secretion (evaluated by iAUC). | 0-240 min following glucose ingestion | Comparison of the GLP-1 responses (evaluated by iAUC) between the two test days. |
Secondary
| Measure | Time frame |
|---|---|
| Difference in insulin responses between the two test days. | 0-240 min following glucose ingestion |
| Difference in C-peptide responses between the two test days. | 0-240 min following glucose ingestion |
| Difference in Gastric Inhibitory Peptide (GIP) responses (evaluated by iAUC) between the two test days. | 0-240 min following glucose ingestion |
| Difference in peptide YY (PYY) responses (evaluated by iAUC) between the two test days. | 0-240 min following carbohydrate ingestion |
| Difference in glucose responses between the two test days. | 0-240 min following glucose ingestion |
| Difference in oxyntomodulin responses (evaluated by iAUC) between the two test days. | 0-240 min following carbohydrate ingestion |
| Difference in cholecystokinin (CCK) responses (evaluated by iAUC) between the two test days. | 0-240 min following glucose ingestion |
| Difference in bile acid responses (evaluated by iAUC) between the two test days. | 0-240 min following glucose ingestion |
| Difference in glucagon responses (evaluated by iAUC) between the two test days. | 0-240 min following glucose ingestion |
Countries
Denmark
Contacts
Primary ContactSten Madsbad, Professor
Outcome results
None listed