Chronic Renal Disease, Hyperuricemia
Conditions
Keywords
Uric Acid, Febuxostat, Chronic Renal Disease
Brief summary
To investigate the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention
Detailed description
This study aims to explore the best effective dose and adverse reaction of febuxostat in lowering serum uric acid to low level in patients with Chronic Renal Disease at different stages. To elucidate that low levels of serum uric acid can delay the progression of renal damage. Promote the application of anti uric acid drugs in the treatment of chronic renal failure and delay the progress of CKD in patients
Interventions
DRUG20mg Febuxostat
Participants take 20mg febuxostat pill once a day for at least six months.
DRUG40mg Febuxostat
Participants take 40mg febuxostat pill once a day for at least six months.
Sponsors
The First People's Hospital of Xuzhou
The Affiliated Hospital of Xuzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Non-dialysis CKD patients with serum uric acid greater than 7mg/dl. * eGFR≥15ml/min/1.73m². * Low salt, low protein, low purine diet.
Exclusion criteria
* Take drugs that raise blood uric acid at the same time. * Patients with gout attacks. * Patients with pregnant, lactating. * Autosomal dominant polycystic kidney disease. * Patients with poor general condition and multiple organ failure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum uric acid | up to 6 months | intravenous blood sampling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum creatinine | up to 6 months | intravenous blood sampling |
Countries
China
Contacts
Primary ContactDong Sun, MD
Outcome results
None listed