Healthy
Conditions
Keywords
Endothelium, vascular, Cardiovascular Disease, Hemodynamics, Oxidative Stress, Dietary Sodium, Dietary Counseling
Brief summary
The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
Detailed description
Cardiovascular disease remains a major Public Health problem and is the leading cause of death in the US. Dietary sodium restriction is considered an important lifestyle modification for individuals with hypertension; however, there is controversy about the effects of dietary salt given that many individuals do not have salt sensitive blood pressure. Deleterious effects of salt on the vasculature may explain the finding that chronic DSR reduces the cardiovascular event rate by 25%despite only minor reductions in BP. It is not known whether dietary sodium restriction improves central pulsatile hemodynamics, known to be related to the development of left ventricular hypertrophy and heart failure risk, and whether the hypothesized improvements in central hemodynamics are similar in men & women. The purpose of this study is to determine the effects of dietary sodium restriction through dietary counseling on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
Interventions
A registered dietician will counsel participants to reduce daily habitual dietary salt intake below 2000mg over 4 weeks
OTHERControl
Participants will consume their routine habitual dietary sodium intake \> 3400mg per day with regular pre determined check in phone calls from a registered dietician.
Sponsors
University of Delaware
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Habitual dietary sodium intake \> 3400mg per day
Exclusion criteria
* Abnormal resting ECG * Current abnormal blood panel (assessed by comprehensive metabolic panel, lipid panel and complete blood count). * Hypertension (currently taking anti-hypertensive medications or resting blood pressure \>140/90 mmHg) * Medical history of cardiovascular disease, malignant cancer, diabetes or kidney disease * Obesity (Body Mass Index \> 30) * Current pregnancy * Unable to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reflected Pulse Wave Amplitude | Change from baseline at 4 weeks | Late systolic pulsatile load on the left ventricle represented by reflected pulse wave amplitude; assessed by echocardiography combined with applanation tonometry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular Function | Change from baseline at 4 weeks | Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis |
| Conduit Artery Endothelial Dependent Dilation | Change from baseline at 4 weeks | Brachial artery flow mediated dilation assessed by duplex ultrasound |
| Arterial Stiffness | Change from baseline at 4 weeks | Carotid - Femoral pulse wave velocity assessed by applanation tonometry |
| Forward pulse wave amplitude | Change from baseline at 4 weeks | Central hemodynamic assessment of the forward pulse wave amplitude assessed by echocardiography combined with applanation tonometry. |
Countries
United States
Outcome results
None listed