Kidney Transplant
Conditions
Keywords
Complications
Brief summary
It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.
Detailed description
The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).
Interventions
OTHERBlood sampling
Descriptive analysis of clinical, biological and histological of 3 arms: ABO incompatible, HLA incompatible, and ABO/HLA incompatible kidney transplantation (1 and 5 years posttransplantation in each groups)
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient receiving a KT and followed at least one year in Toulouse Hospital * Patient who have signed informed consent * \> 18 years old
Exclusion criteria
* Patient under protective measures * Patients treated for cancer, infectious or immune disease by molecules that could interfere with lymphocyte populations : Interleukin 6 (IL6) blockers, Programmed cell death 1(PD1) and the cytotoxic T-lymphocyte-associated antigen 4 (CTL4) blockers. * Immunosuppressive treatments withdrawal - Patient in chronic dialysis * Ongoing pregnancy or pregnancy in the past year * Past of splenectomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gene expression related to antibody mediated rejection | 1 year posttransplantation | To determine expression of genes related to antibody mediated rejection (inflammation, and endothelial cell activation) by transcriptomic analyse (whole genome micro-array) on kidney biopsies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| description of B subsets cells | 1 to 5 years posttransplantation | to analyse of B subsets cells after Kidney transplantation in blood samples of patients by flow cytometry |
| description of lymphocytes rates | 1 to 5 years posttransplantation | to analyse rates of lymphocytes after Kidney transplantation in blood samples of patients by flow cytometry |
| description of T subsets cells | 1 to 5 years posttransplantation | to analyse of T subsets cells after Kidney transplantation in blood samples of patients by flow cytometry |
| Evolution of creatinine clearance | 1 to 5 years posttransplantation | to analyse creatinine clearance in blood samples of patients after kidney transplantation |
| Evolution of systematic annual kidney biopsies | 1 to 5 years posttransplantation | To analyse the evolution of systematic annual kidney biopsies by microscopy |
Countries
France
Outcome results
None listed