Asthma, Asthma-COPD Overlap Syndrome, COPD
Conditions
Keywords
Small airway obstruction, Asthma, COPD, ACOS
Brief summary
This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD
Detailed description
The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.
Interventions
OTHERNo any intervention
No any intervention is applied to any groups in this study
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Physician-diagnosed asthma, ACO, and COPD * Their spirometric, IOS, lung volume, demographic data and sputum samples are available
Exclusion criteria
* Concomitant diseases requiring immunosuppressive therapy * Being on treatments with NSAIDs, macrolides, statins
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lipoxin A4, , | 1 day (single time point) | Lipoxin A4 is measured in sputum supernatants by ELISA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IL-33 | 1 day (single time point) | IL-33 is measured in sputum supernatants by ELISA |
| Thymic stromal lymphopoietin (TSLP) | 1 day (single time point) | TSLP is measured in sputum supernatants by ELISA |
Countries
Thailand
Outcome results
None listed