PET/CT
Conditions
Brief summary
The purpose of this research proposal is to establish a mechanism to develop tools that will allow the investigators to measure the impact of magnetic resonance (MR) acquisition correction sequences for attenuation correction on positron emission tomography (PET) quantitation accuracy.
Interventions
DEVICEPositron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)
FDA approved scanner
Sponsors
National Cancer Institute (NCI)
Washington University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participant must be ≥ 18 years of age * Participant can be a male or a non-pregnant female. * Successful completion of MRI screening form * Participant must have undergone a PET/CT examination with injection of a standard dose of 18F-fluorodeoxyglucose (FDG) or other PET tracer with a half-life greater than one hour either for clinical or research purposes within 3 hrs of the proposed PET-MRI examination. * Participant will be fully informed and has personally signed and dated the written Informed Consent and Health Insurance Portability and Accountability Act (HIPAA) provisions
Exclusion criteria
* Subjects for whom exposure to a strong magnetic field would be a health risk (e.g., subjects with cardiac pacemakers or non-MR compatible metallic implants) * Women who are pregnant. * Subjects who require sedation to participate will be excluded. * Patient/participant has a medical condition which in the judgment of the investigator might make supine positioning for the duration of the scan unsafe, such as (but not limited to) congestive heart failure or significant pulmonary disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure the impact of MR acquisition correction sequences for attenuation correction on PET quantitation accuracy | At the time of the MRI scan | -PET images from PET/MRI with the MR derived attenuation correction will be compared to images generated with the CT attenuation correction from the standard of care PET/CT scan. |
Countries
United States
Outcome results
None listed