Laparoscopic Right Colectomy
Conditions
Brief summary
The short-term advantages of minimally invasive colon resection have been well established in several randomized trials. A major factor in the development of morbidity is the surgical stress response with subsequent increased demand on the patient's reserves and immune competence. Although the advantage in term of stress response of laparoscopic surgery over open surgery has been widely reported, little is known about the role of Intracorporeal anastomosis. In an attempt to evaluate the surgical stress response after totally laparoscopic right colectomy a comparative study has been designed. Two surgical procedures will be evaluated: * Totally laparoscopic right colectomy with intracorporeal anastomosis (Experimental group) * Laparoscopic assisted right colectomy with extracorporeal anastomosis (Control group).
Interventions
PROCEDURELaparoscopic right colectomy
Laparoscopic right colectomy for colorectal cancer with a standard vascular dissection, performing the anastomosis with a side-to-side mechanical anastomosis fashioned intracorporeally versus extra corporeally
Sponsors
Federico II University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
All elective laparoscopic right colectomy for cancer
Exclusion criteria
Urgent procedures Immune depressant therapy Immune depressant disease Post-operative Complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| interleukin 1 | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| interleukin 6 | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| tumor necrosis factor alpha | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| adrenocorticotropic hormone | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| cortisol | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| insulin | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| glucagon | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| C-reactive protein | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| growth hormone | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| prolactin | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
| fibrinogen | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
Countries
Italy
Outcome results
None listed