Breast Cancer, Memory Disorders
Conditions
Brief summary
The results of this study will contribute to a better understanding of prospective memory deficit processes in breast cancer in relation to sleep disorders frequently reported in this pathology. In the long term, a better understanding will make it possible to envisage appropriate treatments to compensate for these memory difficulties and to improve the autonomy of the patients.
Interventions
OTHERNeuropsychological, psycho-pathological and quality of life assessments
Patients and Healthy volunteers perform neuropsychological, psycho-pathological and quality of life assessments, and sleep tests
DRUGHormonotherapy
Adjuvant hormone therapy
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Centre Francois Baclesse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
50 patients including: * 25 patients being treated with adjuvant hormone therapy (Group A) * 25 patients not receiving adjuvant hormone therapy (Group B) * 25 healthy volunteers
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Major patients under the age of 70; * Patients who have been treated by surgery or radiotherapy for non-metastatic breast cancer * Radiotherapy completed for about 6 months * Level of study 3 end of primary studies minimum (Barbizet scale); * French mother tongue; * Menopausal women for at least 1 year before the selection visit * Absence of primary cancer of the central nervous system or brain metastases; * Absence of previous neurological damage; * Absence of personality disorders and progressive psychiatric pathology; * Having signed the informed consent to participate in the study.
Exclusion criteria
* Primary cancer other than breast * Metastatic cancer * Treated by chemotherapy * Cognitive function disorders pre-existing to cancer diagnosis * Patients with paraneoplastic syndrome; * Evolutionary psychiatric pathology; * Refusal of participation; * Patients unable to respond to cognitive tests; * Drug use or excessive consumption of alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The memory components and memory loss mechanisms by questionnaires | 6 months after the end of radiotherapy |
Secondary
| Measure | Time frame |
|---|---|
| The effect of sleep quality on the recovery of intentions in prospective memory by questionnaires | 6 months after the end of radiotherapy |
| The impact of adjuvant hormone therapy on the functioning of prospective memory by questionnaires | 6 months after the end of radiotherapy |
| The influence of anxio-depressive factors and fatigue on prospective memory by questionnaires | 6 months after the end of radiotherapy |
Countries
France
Outcome results
None listed