The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Patients With Migraine

The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Chinese Patients With Migraine:a Multicenter Study. CAMBRAIN Study.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03418766

Acronym

CAMBRAIN

Enrollment

1500

Registered

2018-02-01

Start date

2018-06-15

Completion date

2020-12-30

Last updated

2020-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine Disorders, Right-to-left Shunt, White Matter Disease

Keywords

Right-to-left Shunt, Brain White Matter Lesions, Migraine

Brief summary

The purpose of the study is to evaluate the prevalence of white matter lesions in Chinese migraineurs with and without right-to-left shunt. The aim is to study the relationship among right-to-left shunt, migraine and white matter lesions.

Detailed description

This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and migraine diagnosis). For all the participants, brain MRI and c-TCD are required. Up to 10-15 study sites nationwide will be needed to recruit the planned participant population during a 1-year period. The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, and Headache Impact Test-6 (HIT-6) questionnaire.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* patients who fulfilled the criteria for migraine according to the International Classification of Headache Disorders III-beta were included. healthy volunteers without a history of migraine were included as controls.

Exclusion criteria

* Subjects were excluded from the study if they had severe arterial stenosis, an insufficient temporal window, inadequate cubital venous access, and/or were unable to perform the Valsalva manoeuvre (VM) because of severe heart or lung disease.

Design outcomes

Primary

Measure	Time frame	Description
contrast-enhanced transcranial Doppler (c-TCD)	1 year	Brain MRI

Countries

China

Contacts

Primary ContactYingqi Xing, MD,PhD

xingyq2009@sina.com15844047846

Backup ContactSibo Wang, MD,PhD

wangsibo92@163.com15844008297

Outcome results