IPF, Reflux
Conditions
Brief summary
The primary objective of this study is to show that the Supraglottic Index (SGI) is an easily-collected index that accurately identifies the presence and severity of laryngopharyngeal reflux (LPF) in idiopathic pulmonary fibrosis (IPF).
Detailed description
The study team hypothesizes the SGI will correlate more strongly with measures of IPF severity (at baseline and over time) than gastroesophageal reflux (GER) data derived from the esophageal detector channels of a pH/impedance probe.
Interventions
None listed
Sponsors
National Jewish Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of IPF * Age 40-95 * Able to read, speak, and understand English * If subjects are currently taking medication for reflux or GERD, they much be on a stable does for at least 4 weeks prior to consent.
Exclusion criteria
* Patients who do not meet all inclusion criteria * Pregnant females
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The supraglottic index (SGI) quantifies laryngopharyngeal reflux (LPF) and is associated with severity of pulmonary fibrosis. | 6 months | Correlation between the supraglottic index and forced vital capacity. The supraglottic index is an index derived by assigning scores for edema and erythema of five supraglottic structures (epiglottis, false cords, arytenoids, posterior commissure, piriform recess) as viewed through a fiber-optic scope. Scores range from 0-22, with higher scores indicating more severe LPR. |
Countries
United States
Contacts
Primary ContactMatthew Koslow, MPH
Outcome results
None listed