Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Effects of General Anesthesia With Propofol Versus Desflurane on Oxidative Stress and Inflammation in Obese Patients Scheduled for Bariatric Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03417518

Enrollment

Registered

2018-01-31

Start date

2015-01-31

Completion date

2016-09-30

Last updated

2018-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Obesity

Keywords

Oxidative stress, Bariatric surgery

Brief summary

Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.

Detailed description

Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.

Interventions

DRUGDesflurane Inhalant Product

General anesthesia will be induced with sufentanyl (0.2µg/kg) and thiopental (5mg/kg) and maintained by desflurane

DRUGPropofol

General anesthesia will be induced with propofol (2mg/kg) and sufentanyl (0.2µg/kg) and maintained by propofol in a target-controlled infusion mode

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Body Mass Index (BMI) \>35 * scheduled gastric by pass surgery * American Society of Anesthesiologists (ASA) \<III

Exclusion criteria

* Allergic to anesthesia agent * patient refusal

Design outcomes

Primary

Measure	Time frame	Description
Malondialdehyde (MDA) level in blood sample	up to 24 hours post bariatric surgery	Plasma MDA level is measured as an oxidative stress marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.

Secondary

Measure	Time frame	Description
C-Reactive Protein (CRP) in blood sample	up to 24 hours post bariatric surgery	Plasma CRP level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.
Monocyte level in blood sample	up to 24 hours post bariatric surgery	Monocyte level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.
Pain assessed by Visual Analog Scale (VAS)	up to 48 hours after surgery	Pain level is determined at 2 hours, 24 hours and 48 hours post-surgical incision. Visual analog pain score (scale = 0 no pain; 10= worst pain imaginable)
Side-effects (nausea, vomiting, somnolence, respiratory depression)	up to 48 hours after surgery	Evaluation at 2 hours, 24 hours and 48 hours post-surgical incision

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026