Indications and Interest of US-guided Synovial Biopsies Performed in Clinical Practice

Interest of Synovial Biopsy in the Etiological Assessment of Arthritis of Undetermined Origin: Multicenter Prospective Series

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03417167

Acronym

BIOPSYN

Enrollment

201

Registered

2018-01-31

Start date

2018-02-14

Completion date

2020-09-11

Last updated

2020-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthritis

Keywords

synovial biopsy, US guided synovial biopsy

Brief summary

Synovial biopsies are now routinely performed both in research and in clinical practice. The developments of ultrasound (US) and of US-guided needle biopsies devices have facilitated their use and tolerance by the patients. However, their interest in clinical practice in the context of an undifferentiated arthritis remains debated.

Detailed description

In this study, the investigators will collect all the synovial biopsies performed in clinical practice in 18 Rheumatology Unit throughout France. All the participants received a standardized training on US-guided synovial biopsies. For each biopsy, the indications, clinical presentation, procedure (length, tolerance), biopsy results (Pathology, bacteriology, etc ...) will be collected in a Clinical Research Form. The investigator will determine the number of cases where the synovial biopsy allows drawing a definite diagnosis.

Interventions

OTHERUS-guided synovial biopsy

Needle Synovial biopsy performed using a Tru-cut® device.

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

All patients undergoing an US-guided synovial biopsy in clinical practice in the context of an arthritis of unknown origin

Design outcomes

Primary

Measure	Time frame	Description
number of cases where the synovial biopsy allows drawing a definite diagnosis	10 days	Final diagnosis will be classified in 5 groups: infectious, crystal induced arthritis, tumoral, inflammatory rheumatisms, others (amyloidosis etc …)

Secondary

Measure	Time frame	Description
Indications, tolerance, complications, number and type of analysis for each sample, results of pathology, bacteriology, mycobacteriology	1 month	For each biopsy, the indications, clinical presentation, procedure (length, tolerance), biopsy results (Pathology, bacteriology, etc ...) will be collected in a Clinical Research Form.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026