Superior Mesenteric Artery Syndrome
Conditions
Keywords
Superior Mesenteric Artery Syndrome, Chronic duodenal obstruction, Duodenojejunostomy, Wilkie's syndrome
Brief summary
Superior Mesenteric Artery Syndrome (SMAS) is a rare cause of duodenal obstruction, that should be suspected in cases of chronic, refractory upper digestive symptoms. Between 2008 and 2016, 39 consecutive patients with chronic gastrointestinal symptoms and a diagnosis of SMAS were prospectively included in the study, in order to describe their demographic, clinical and outcome features. All patients underwent duodenojejunostomy.
Interventions
PROCEDUREDuodenojejunostomy
Duodenojejunostomy with or without duodenal resection
Sponsors
Azienda Ospedaliera di Padova
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
(at least 2 of the following): * severe and frequent upper digestive symptoms (occurring at least once a week), associated to poor quality of life and refractory response to medical treatment; * a condition of underweight (BMI \<18.5 kg/m2) associated with difficulty eating; * severe complications of SMAS (e.g. gastric perforation, acute pancreatitis, aspiration pneumonia); * suggestive findings of SMAS at barium swallow; * diagnostic aortomesenteric angle and distance at CT/MR angiography.
Exclusion criteria
* inability to provide the informed consent; * malignancies; * bowel motility disorders; * severe psychiatric illness; * pregnancy; * impossibility to perform the required diagnostic workup.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Symptom score | 47 months (IQR 34-72) | Severity (0-6) + frequency (0-5) x 5 symptoms (abd pain, nausea, vomiting, reflux, bloating) |
| BMI | 47 months (IQR 34-72) | Body mass index |
| Need for medical treatment | 47 months (IQR 34-72) | PPIs, prokinetic drugs |
Countries
Italy
Outcome results
None listed