TMAO and Atherosclerosis in HIV

Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03416257

Enrollment

737

Registered

2018-01-31

Start date

2004-04-12

Completion date

2017-04-04

Last updated

2018-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Artery Plaque

Brief summary

In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).

Interventions

OTHERNo intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* participants who underwent carotid artery imaging for plaque assessment at a baseline visit (2004-2006) and at a follow-up visit (2011-2013).

Exclusion criteria

* a history of coronary heart disease, individuals with prevalent diabetes or prevalent carotid artery plaques at baseline

Design outcomes

Primary

Measure	Time frame	Description
incident carotid artery plaque	2011-2013	assessed by repeated B-mode carotid artery ultrasound imaging

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026