Siewert Type II Adenocarcinoma of Esophagogastric Junction
Conditions
Keywords
esophageal cancer, adenocarcinoma of the esophagus, esophageal surgery
Brief summary
In Siewert type II adenocarcinoma, the relationship between adenocarcinoma sub types and survival, histologic/biologic patterns related to the presence/absence of gastric greater curvature metastases, were investigated.
Detailed description
In order to achieve further data on the biological patterns of intestinal and diffuse subtypes of esophageal adenocarcinoma (Lauren's classification), on the frequency of gastric greater curvature nodal stations and on the clinical relevance, in terms of prognosis and survival, of these parameters, a Siewert type II case series of Siewert type II adenocarcinomas, submitted to primary (no neoadjuvant therapy) surgical, studied, operated upon and followed up, were analysed. According to histologic patterns, cases were ordered in intestinal and diffuse adenocarcinoma sub types (Lauren's classification)and distinguished in Barret's, cardiopyloric, gastric types.
Interventions
PROCEDURETotal Gastrectomy
The esophagus was resected at the arch level of the azygos vein, a frozen section of the resection margin was routinely performed to achieve a proximal clean resection margin. The surgical specimen was comprehensive of distal esophagus, stomach and omentum. Digestive tract continuity was established with Roux-en-Y esophagojejunostomy. Lymphadenectomy was extended to the thoracic stations R 2-4, 7-8-9, and L 4, numbered according to the Mountain's classification \[39\] (Suppl. File 2 Figure A) and to the abdominal stations 1-12, numbered according to the Japanese Research Society for Gastric Cancer (JRSGC) 1998 classification.
Sponsors
University of Bologna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Siewert type II adenocarcinoma \> 18 year submitted to primary surgery
Exclusion criteria
Siewert type II adenocarcinoma submitted to neoadjuvant therapy. Siewert type I adenocarcinoma. Siewert type III adenocarcinoma Squamous Carcinoma \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival | 5 years | 5 year survival between intestinal and diffuse types (Lauren's classification) of Siewert type II adenocarcinoma after primary surgery, |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of gastric greater curvature lymph nodes metastases in Siewert II adenocarcinoma | 5 years | Frequency of gastric greater curvature lymph nodes metastases and survival |
Countries
Italy
Outcome results
None listed