Retinal Microcirculation Disorder
Conditions
Keywords
Beverage consumption, Reading, Body motion, Retinal microcirculation, Optical coherence tomography angiography, Magnetic resonance imaging
Brief summary
The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.
Interventions
BEHAVIORALBeverage consumption
The participants drink 300ml wine (alcohol concentration:12.5%)or 300ml coffee (caffeine concentration 72 mg), or water.
BEHAVIORALDaily reading
Reading paper books, playing video games with mobile phones, or non-reading for 8 hours.
BEHAVIORALBody motion
Exercise or body postural changes
Sponsors
Jiannan Huang
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Masking description
Data analyzers are blind to the participants classification
Intervention model description
1. Influence of beverage consumption Participants drink coffee, red wine, Baijiu (Chinese liquor), grape juice, and water respectively on three mornings with one-week washout. Each period lasts 2 hours. An additional test with SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption. OCTA and MRI scanning are taken every 30 minutes, and venous blood is collected. 2. Influence of daily reading 30 participants read paper books, play video games with mobile phones, and non-read respectively on three mornings interval with one-week washout. OCTA and MRI scanning are taken every 2 hours for a total of 8 hours. 3. Influence of body motion Exercise: 30 participants are enrolled. Participants undergo to jogging for 10 minutes, 30 minutes, and 1 hour respectively on three mornings with a 3-day washout. Body postural changes: 30 participants are enrolled. OCTA and MRI scanning are taken before and after jogging or body postural changes.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy adults 2. The age range was from 18 to 35 years old 3. Without another eye disease besides ametropia 4. The spherical equivalent is equal or above minus 3.00 diopters 5. No smoking or drinking 6. Average daily caffeine consumption no more than 1 cup of coffee 7. No diabetes, hypertension, heart disease, liver or kidney dysfunction 8. No medication taken recently
Exclusion criteria
1. Mental disorders such as depression and anxiety 2. Intellectual disabilities 3. Female in menstruation, gestation period, perinatal period or lactation period 4. Unable to cooperate with eye examinations and test procedures 5. Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases 6. Patients with fever, acute infectious diseases 7. Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vessel diameter index (VDI) | 3 weeks | VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber. |
| Vessel area density (VAD) | 3 weeks | VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps. |
| Flow impairment region (FIR) | 3 weeks | FIZ: calculated by summing all 'no-flow' pixels up. |
| Retina-choroid blood flow | 3 weeks | Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values. |
| Cerebral blood flow (CBF) | 3 weeks | The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF |
Countries
China
Outcome results
None listed