Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified, Suxamethonium Sensitivity
Conditions
Brief summary
Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content. Whereas other myorelaxant agents are monitored with train of four stimulation to assess onset and duration, few anesthesiologists use train of four stimulation for onset of succinylcholine, as the anesthesiologists evaluate the effect with the time from injection (usually one minute) and the muscle fasciculation due to the release of acetylcholine. The data available on onset duration of this drug are old and bases on only few studies, but the succinylcholine if sometime harmful (anaphylaxis , cardiac arrest, bronchospasm). The investigators want to assess the onset time of succinylcholine with an objective toll , the train of four stimulation, and evaluate if the clinical judgment of the anesthesiologist is reliable to predict an adequate moment for endotracheal intubation.
Interventions
None listed
Sponsors
University Hospital, Caen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Every patient undergoing general anesthesia with the use of suxamethonium for induction as assessed by the anesthesiologist
Exclusion criteria
* Patient under 18 years old * Pregnant woman * Nasotracheal intubation * Monitoring of train of four at the adductor pollis impossible (such as patient with no arm )
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Onset of action of suxamethonium as assessed by the measurement of the train of four stimulation at the adductor pollis | 60 seconds after the injection of suxamethonium | Time, in seconds, between injection of suxamethonium and appearance of a value of zero on the train of four stimulation measurement (going to for on for to zero on for). |
| Time from suxamethonium injection to laryngoscopy | 60 seconds after the injection of suxamethonium | Time, in seconds, between the injection of suxamethonium and the laryngoscopy realized by the anesthesiologist. |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients whom train of four was not 0 when they benefited from the laryngoscopy | 60 seconds after the injection of suxamethonium |
| Complications associated with use of suwamethnonium or early laryngoscopy | 60 seconds after the injection of suxamethonium |
| Main characteristics of the patients and intubation conditions | 60 seconds after the injection of suxamethonium |
Countries
France
Contacts
Primary ContactClément Buléon, PH
Backup ContactRaphaël d'Orlando
Outcome results
None listed