Hyperlipidemias, Triglycerides High
Conditions
Keywords
Postprandial lipid metabolism, Medium-chain triglycerides, Diacylglycerols, Serum triglycerides, Chylomicron triglycerides
Brief summary
It is well known that medium chain triglycerides (MCTs) and diacylglycerols (DGs) have effects on lowering circulating triglycerides (TGs). In this study, the mixture of MCTs and DGs (MCDGs) examined whether it has beneficial effects on postprandial lipids metabolism compared to long-chain triglycerides (TGs).
Detailed description
A randomized, double-blinded, controlled, cross-over trial was conducted to verify the effects of MCDGs. Twenty-eight healthy male and female subjects aged 21-29 years with normal body weight \[18.5 kg/m\^2 ≤ body mass index (BMI) \< 25 kg/m\^2\] were recruited. The subjects visited the research site twice over with a seven-day interval after an overnight fast at least 12 hr. On the first visit, the participants were randomly assigned to consume a test or placebo product \[test product: muffins containing MCDG oil (MCDG muffin); placebo product: muffins containing LCT oil (LCT muffin)\] and ingested the assigned product. On the second visit, the participants consumed the other product that they did not eat on the first visit. On both visit day, the 6-hr meal tolerance test was conducted and started at 8:00 in the morning; venous blood samples were collected before (0 hr) and after ingestion (2, 3, 4, and 6 hr) of the products.
Interventions
DIETARY_SUPPLEMENTLCT oil
LCT muffin was provided to the study participants. The LCT muffin was consumed within 15 min, and then 6-h meal tolerance test was conducted. The muffin had approximately 465 kcal, 8.36 g of protein, 17.24 g of fat, and 69.0 g of carbohydrate; among the 17.24g of fat, 15g of fat was LCT.
DIETARY_SUPPLEMENTMCDG oil
MCDG muffin was provided to the study participants. The MCDG muffin was consumed within 15 min, and then 6-h meal tolerance test was conducted. The muffin had approximately 465 kcal, 8.36 g of protein, 17.24 g of fat, and 69.0 g of carbohydrate; among the 17.24g of fat, 15g of fat was MCDG.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects with normal body weight (18.5 kg/m\^2 ≤ body mass index (BMI) \< 25 kg/m\^2)
Exclusion criteria
* history/presence of hypertension, diabetes mellitus, hyperlipidemia, cardiovascular disease, liver disease, gastrointestinal disease, thyroid disease, or any other acute or chronic diseases requiring treatment * Use of any medication affecting body weight or energy expenditure for 1 month before screening
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Triglyceride levels | 6 hours | Triglyceride level differences during the 6-hr meal tolerance test between LCT and MCDG muffins intake |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The areas under the curve (AUC) of triglycerides | 1 day of second visit (after finishing cross-over trial) | Triglyceride AUC differences between LCT and MCDG muffins intake |
| Triglyceride maximum concentration time | 1 day of second visit (after finishing cross-over trial) | The time when triglyceride peaks maximum concentration during the 6-h meal tolerance test |
Countries
South Korea
Outcome results
None listed