Dyslipidemias
Conditions
Keywords
anthocyanins, dyslipidemias, dose response
Brief summary
In order to study the effect of anthocyanins on the improvement of glucose and lipid metabolism, randomized intervention trials were conducted to compare the effects of anthocyanins on the improvement of glucose and lipid metabolism in different dose groups.To explore the best dose of anthocyanins for the prevention and treatment of anthocyanin metabolic diseases provide an important scientific basis.
Detailed description
In order to study the effect of anthocyanins on the improvement of glucose and lipid metabolism, randomized controlled trials were conducted to enrolled 300 patients with dyslipidemia. The subjects were divided into 0 mg / d, 40 mg / d, 80 mg / d, 320 mg/ d five dose groups, intervention for 12 weeks, comparing different doses of anthocyanins on glucose and lipid metabolism.To explore the best dose of anthocyanins for the prevention and treatment of anthocyanin metabolic diseases provide an important scientific basis.
Interventions
DRUGMedox® Anthocyanin capsules
Subjects were orally administered Medox® capsules daily for 12 weeks.
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Dyslipidemia * Subjects with dyslipidemia who also have prediabetes * The age between 35 and 70 years old
Exclusion criteria
* intake of any medicine that affect lipid and glucose metabolism currently or in the preceding 6 months * dietary supplementation with phytochemicals including anthocyanins in the preceding 2 months * history of acute or chronic infectious disease, autoimmune disease, cancer, traumatic injury, or surgery in the preceding 1 month * history of severe chronic disease including AS and CVD, liver or renal dysfunction, and lactation or pregnancy * Pregnant woman and Breast Feeding Women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anthocyanins dose-dependently improved blood lipids in patients with dyslipidemia. | 12 weeks | After 12 weeks intervention of anthocyanins, serum lipid profiles were measured at baseline, at 6 weeks, and at the end of 12 weeks. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anthocyanin supplementation improves cholesterol efflux capacity in a dose-response manner in subjects with dyslipidemia | 12 weeks | After 12 weeks intervention of anthocyanins,cholesterol efflux capacity (CEC) were measured at baseline, at 6 weeks, and at the end of 12 weeks. |
| Anthocyanins supplementation improve anti-oxidative and anti-inflammation capacity in a dose-response manner in subjects with dyslipidemia. | 12 weeks | After 12 weeks intervention of anthocyanins,Urine 8-iso-prostaglandinF2α (8-iso-PGF2α), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and serum malondialdehyde (MDA), superoxide dismutase (SOD), UA (urine acid), interleukin-6 (IL-6), interleukin-10(IL-10), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured at baseline, at 6 weeks and at the end of 12 weeks. |
| Anthocyanins supplementation attenuate platelet hyperreactivity in a dose-response manner in subjects with dyslipidemia. | 12 weeks | After 12 weeks intervention of anthocyanins, platelet aggregation, the expression of P-selectin (CD62p) activated GPⅡbⅢa (PAC-1), platelet reactive oxygen species (ROS) and platelet mitochondrial membrane potential (TMRM) were measured at baseline, at 6 weeks and at the end of 12 weeks. |
Countries
China
Outcome results
None listed