Chronic Migraine
Conditions
Keywords
Transcranial Direct Current Stimulation, Migraine Disorders, Cognitive Symptoms
Brief summary
This study aims to compare the effects of transcranial direct current stimulation on the clinical and cognitive function in patients with chronic migraine.
Detailed description
The patients will be randomized into 1 of 3 groups: active tDCS for 15 minutes, active tDCS for 15 minutes, with an interval of 20 minutes and more 15 minutes os stimulation, sham tDCS for 15 minutes. The tDCS will be applied for 10 days over 2 weeks.
Interventions
OTHERtDCS
Transcranial Current Stimulation equipment consists of an ammeter (measured with current intensity), a potentiometer (voltage controller between the electrodes), a generator (two 9-volt batteries) and two electrodes (anode and cathode). The direct low-amplitude currents released by the electrodes reach the cortex and modify the neuronal potentials.
Sponsors
Federal University of Paraíba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
The patients will be randomized into 1 of 3 groups: group A: active tDCS for 15 minutes, group B: active tDCS for 15 minutes, with an interval of 20 minutes and group C: more 15 minutes os stimulation, sham tDCS for 15 minutes.
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* females * clinical diagnosis of chronic migraine according to the International Classification of Headaches Disorders (ICHD-3 beta).
Exclusion criteria
* headache attributable to some pathological condition, associated neurologic or neuropsychiatric disease * use of central nervous system modulating drugs * pregnancy * metallic head implants * use of a cardiac pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Migraine Disability Assessment - MIDAS | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in perform activities of daily living associate to migraine assessed on the Migraine Disability Assessment - MIDAS. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wechsler Intelligence Scale Letters | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Letters |
| Wechsler Intelligence Scale Numbers Test | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Numbers Test |
| Hayling's Test Hayling's Test | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in operational memory assessed on the Hayling's Test Evaluate operational memory |
| Trail Making Test part B | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in executive functions assessed on the Trail Making Test part B |
| Salthouse Visual Patterns and Lyrics | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in visual processing speed assessed on the Salthouse Visual Patterns and Lyrics |
| Headache Impact Test - HIT-6 | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in quality of life associate to migraine assessed on the Headache Impact Test-6 (HIT-6) |
| Paced Auditory Serial Addition Task | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in selective attention assessed on the Paced Auditory Serial Addition Task |
| Concentrated Attention Test | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in selective attention assessed on the Concentrated Attention Test |
| Visual Attention Test (Attention Matrices) | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in selective attention assessed on the Visual Attention Test (Attention Matrices) |
| Montreal Cognitive Assessment | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in cognition assessed on the Montreal Cognitive Assessment |
| Side Effects Questionnaire | every day for up to 2 weeks | adverse effects assessment |
| Nine Hole Peg Test | before treatment, after treatment - up to 2 weeks and up to 1 month after the last day of treatment | Change in the motor processing speed assessed on the Nine Hole Peg Test |
Countries
Brazil
Outcome results
None listed