Frailty in Older HIV-infected Individuals

Frailty in Older HIV-infected Individuals in Hong Kong: Risk Factors and Association With Quality of Life and Mortality

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03413683

Enrollment

100

Registered

2018-01-29

Start date

2018-04-01

Completion date

2028-01-31

Last updated

2023-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infections

Brief summary

Frailty has been proposed as a measure of biological (as opposed to chronological) aging. In this study the investigators plan to: (1) measure frailty in a cohort of older HIV-infected individuals in Hong Kong, and its association with mortality and quality of life; (2) identify risk factors predictive of development of frailty in HIV-infected individuals in Hong Kong; and (3) determine the outcomes of HIV-infected individuals in Hong Kong with and without frailty. The following assessment will be done: 1. Physical examination including measuring height, weight, hip and waist circumference. 2. Grip strength, chair stand test, gait speed test, balance tests, and neurocognitive tests 3. Geriatric syndromes, screening for depression, disability and quality of life. 4. Blood tests during fasting state to measure metabolic parameters. This is a prospective longitudinal observational study that lasts for 10 years.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Inclusion criteria

* HIV infection with positive anti-HIV antibody * Age ≥50 years

Exclusion criteria

* Refuses to consent

Design outcomes

Primary

Measure	Time frame	Description
Frailty	10 years	Frailty defined by frailty phenotype measurement, according to Fried (Fried et al., 2011) definition.

Countries

Hong Kong

Contacts

Primary ContactRity Wong

ritywong@cuhk.edu.hk+85235053376

Backup ContactGrace Lui

gracelui@cuhk.edu.hk+85235051464

Outcome results