Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis

Clinical And Microbiological Evaluations Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03412331

Enrollment

Registered

2018-01-26

Start date

2008-01-31

Completion date

2012-09-30

Last updated

2018-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Aggressive Periodontitis

Brief summary

Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occuring in young individuals. Photodynamic therapy (PDT) was introduced in periodontology as an adjunctive approach to non-surgical periodontal treatment (NPT) in periodontitis patients. In this trial, it was aimed that to evaluate the clinical and microbiological effects of adjunctive PDT to NPT in patients with GAgP. In this prospective controlled clinical study, 24 systemically healthy, non-smoking subjects with GAgP were enrolled. Subjects were randomly assigned to a control group (n=12) treated with NPT only or to a test group (n=12) treated with NPT and PDT. Plaque index, sulcus bleeding index (SBI), pocket depth (PD), relative attachment level, gingival recession, mobility were recorded at baseline and on day 63. Microbiological samples were obtained fom the sites with PD ≥5 mm at the same time points and evaluated for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola using micro-IDent test.

Interventions

DEVICEUltrasonic

Cavitron® BOBCAT® Pro, Dentsply International, USA

DEVICEHand Instruments

Gracey, SG 5/6, 7/8, 11/12, 13/14, Hu-Friedy Ins. Co., USA

DEVICELED Source

LED source (625-635 nm wavelength) (FotoSan®, CMS Dental, Denmark)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* systemically healthy, * non-smoker * not received any periodontal treatment within the last 6 months * no antibiotics, anti-inflammatory drugs or any other medication taken within the last 6 months * consent to participate in the study

Exclusion criteria

* any systemic disease (i.e. diabetes mellitus, HIV infection) that might influence the prognosis of periodontal disease and outcome of the treatment * any medical condition that required antibiotic prophylaxis before the treatment * smoking * pregnancy and lactation * ingestion of antibiotics, anti-inflammatory drugs or any other medication during study period * any physical limitations or restrictions that might preclude normal oral hygiene procedures

Design outcomes

Primary

Measure	Time frame	Description
Probing Depth	63 day	defined as the distance from the free gingival margin to the bottom of the periodontal pocket

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026