Respiratory Management of Preterm Infants and Bronchopulmonary Dysplasia

The Impact of Modifications on Respiratory Management of Preterm Infants on the Death or Bronchopulmonary Dysplasia Outcome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03411018

Enrollment

600

Registered

2018-01-25

Start date

2012-01-01

Completion date

2017-12-31

Last updated

2021-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary Dysplasia

Keywords

lung protective strategies, Less invasive respiratory support, preterm infant

Brief summary

This observational study evaluates the impact of respiratory management modifications implemented in our institution on the intubation rates and the death or Bronchopulmonary Dysplasia (BPD) outcome.

Detailed description

Less invasive respiratory management has been implemented in most neonatal units as well as lung protective ventilatory strategies when intubation is required in order to minimize ventilator induced lung injury. In our institution a new ventilatory protocol including less invasive surfactant administration, Synchronized nasal positive pressure ventilation and early rescue High frequency ventilation has been implemented during 2013-14. Hypothesis: New less invasive and lung protective strategies to prevent lung injury had been effective in reducing intubation rates.

Interventions

OTHERMechanical ventilation exposure

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 36 Weeks

Healthy volunteers

Inclusion criteria

All preterm Infants born with less than 32wGA admitted in our NICU.

Exclusion criteria

Congenital malformations and Known Chromosomal disorders,

Design outcomes

Primary

Measure	Time frame	Description
BRONCHOPULMONARY DySPLASIA	36 weeks of postmenstrual age.	Diagnosis of moderate-severe bronchopulmonary dysplasia (physiological definition)
mortality	before discharge	death

Secondary

Measure	Time frame	Description
Mechanical ventilation	during hospitalization	requirement of mechanical ventilation

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026