Morbid Obesity
Conditions
Brief summary
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on oesophageal symptoms and disease, including the presence of Barrett oesophagus ≥ 5 years post-surgery.
Detailed description
Bariatric surgery shows impressive results in terms of weight loss and resolution of comorbidities. Still, there are questions as to the frequency of long-term adverse effects: the prevalence and causes of post-operative swallowing disorders and reflux disease are uncertain. Recently, independent study groups described a high incidence of Barrett oesophagus post LSG. Additional research is urgently needed. The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on oesophageal symptoms and disease, including the presence of Barrett oesophagus ≥ 5 years post-surgery.
Interventions
DIAGNOSTIC_TESTGastroscopy
in both arms intervention 'gastroscopy' will be carried out
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who received laparoscopic gastric bypass or laparoscopic sleeve gastrectomy ≥ 5 years ago as a primary bariatric procedure will be eligible for this study.
Exclusion criteria
* Patients who received laparoscopic gastric bypass or laparoscopic sleeve gastrectomy as a secondary bariatric procedure (e.g. after gastric banding), * Patients who received a secondary bariatric operation after laparoscopic gastric bypass or laparoscopic sleeve gastrectomy( e.g. biliopancreatic diversion)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Barrett oesophagus after bariatric surgery | 5-7 years after bariatric surgery | incidence of Barrett oesophagus will be compared to will be compared to reference for this age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of dysphagia after bariatric surgery | 5-7 years after bariatric surgery | Prevalence of dysphagia will be compared to will be compared to reference for this age |
| Prevalence of oesophageal motility disorders after bariatric surgery | 5-7 years after bariatric surgery | Prevalence of oesophageal motility will be compared to will be compared to reference for this age |
Countries
Switzerland
Outcome results
None listed