Lung Injury
Conditions
Brief summary
Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown.
Detailed description
Background. Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown. Weaning of propylene glycol/glycerol could allows a quick clearance of propylene glycol/glycerol from the body, with subsequent recovery of cardiorespiratory function. Specific aim of the research. This research proposal tests the following hypothesis regarding the reversibility of propylene glycol/glycerol and nicotine intake: * Propylene glycol/glycerol cessation restores cardiorespiratory function. * Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine proteomics profile, which are partially reversed after cessation. * Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine metabolomics profile, which are partially reversed after cessation.
Interventions
OTHERNicotine intake
The participant will pursuit his regular nicotinic propylene/glycerol intake five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol (mix 50:50) intake.
OTHERCessation intake
The participant will completely stop his regular nicotinic propylene/glycerol intake during five days before the session. At the start of the experimental session, participants will mimick intake with the device turns off.
OTHERNicotine free intake
The participant will wean off nicotine during five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol (mix 50:50) intake.
Sponsors
Université Libre de Bruxelles
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject must be regular propylene glycol/glycerol/nicotine intake users since at least 1 year * Subject must be former smokers
Exclusion criteria
* Chronic or acute illness * Substance abuse * Chronic medication intake
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cardiorespiratory function | 4 hours | Continuous monitoring of cardiorespiratory function |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum and urine proteomics profiles | 1 hour | Serum and urine proteomics |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in serum and exhaled breath condensate metabolomics profiles | 1 hour | Serum and exhaled breath condensate metabolomics |
Countries
Belgium
Outcome results
None listed