Morbid Obesity
Conditions
Brief summary
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
Detailed description
Bariatric surgery shows impressive results in terms of weight loss and resolution of comorbidities. Still, there are questions as to the frequency of long-term adverse effects: data on alterations in bone health are missing, The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
Interventions
DIAGNOSTIC_TESTDEXA (= Dual-energy x-ray absorptiometry)
measurement of vertebral bone and hip bone mineral density
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who received laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastric bypass (LRYGB) ≥ 5 years ago as a primary bariatric procedure will be eligible for this study.
Exclusion criteria
* LSG or LRYGB as a secondary bariatric procedure (e.g. after gastric banding), patients receiving secondary bariatric operation after LSG resp LRYGB (e.g. biliopancreatic diversion), pregnancy (due to radiation exposition)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total hip T-Score measured with dual-energy x-ray absorptiometry | 5-7 years after bariatric surgery | measured score will be compared to reference score for this age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total vertebral T-Score measured with dual-energy x-ray absorptiometry | 5-7 years after bariatric surgery | measured score will be compared to reference score for this age |
| fracture risk assessed by FRAX score | 5-7 years after bariatric surgery | measured score will be compared to reference score for this age |
| plasma concentration of C-terminal telopeptide (CTX) | 5-7 years after bariatric surgery | measured plasma concentration will be compared to reference for this age |
| plasma concentration of vitamin D3 | 5-7 years after bariatric surgery | measured plasma concentration will be compared to reference for this age |
Countries
Switzerland
Outcome results
None listed