Effect of Ramosetron on Post-discharge Nausea and Vomiting

Effect of Ramosetron on Post-discharge Nausea and Vomiting in Patients Undergoing Gynecologic Surgery Through a Day-surgery Center

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03409835

Enrollment

100

Registered

2018-01-24

Start date

2018-03-01

Completion date

2019-06-30

Last updated

2018-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopy

Brief summary

Nausea and vomiting after general anesthesia is one of the common anesthetic complications. If the patient is discharged from the hospital after surgery, proper treatment may be delayed or impossible if nausea or vomiting occurs. Thus, It is necessary to prevent these symptoms beforehand. Patients who underwent gynecologic surgery will be treated with prophylactic ramosetron to determine whether the frequency of nausea and vomiting is decreased when the patient returned home after discharge.

Interventions

DRUGRamosetron

Ramosetron 0.3 mg is administered after induction of general anesthesia.

DRUGNormal saline

Normal saline 2 ml is administered after induction of general anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patients who undergo hysteroscopic surgery and are discharged on the day of surgery.

Exclusion criteria

* American Society of Anesthesiologists physical statue 3 or more * Planned admission after surgery * Intravenous anesthesia * During chemotherapy * Pregnancy or breastfeeding * Abnormal liver or kidney function

Design outcomes

Primary

Measure	Time frame
The change in the occurrence of postoperative nausea	Postoperative 30 minute, 3 hour, 24 hour, and 48 hour
The change in the occurrence of postoperative vomiting	Postoperative 30 minute, 3 hour, 24 hour, and 48 hour

Secondary

Measure	Time frame	Description
The change of postoperative pain score	Postoperative 30 minute, 3 hour, 24 hour, and 48 hour	Score range is from 0 to 10.
The change in the number of postoperative administration of rescue analgesic drug	Postoperative 30 minute and 3 hour	—
The change in the number of postoperative administration of rescue antiemetic drug	Postoperative 30 minute and 3 hour	—
The change of patient's satisfaction score	Postoperative 30 minute, 3 hour, 24 hour, and 48 hour	Score range is from 0 to 10.

Countries

South Korea

Contacts

Primary ContactHyo-Seok Na

hsknana@gmail.com1087012913

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026