Differences in Immunologic Response to Cryoablation Versus Radiofrequency Ablation in the Treatment of Renal Cell Carcinoma

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03409224

Enrollment

Registered

2018-01-24

Start date

2003-01-31

Completion date

2019-04-30

Last updated

2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune Response to 3 Approaches

Brief summary

The purpose of this study is to compare changes in the body's self-defense (immune response) after two different treatments for small kidney tumors: 1) Cryoablation (freezing) therapy in which the tumor and a margin of normal kidney tissue are frozen and thawed twice with a needle probe and 2) radiofrequency ablation (RFA) in which radiofrequency energy delivered through a needle probe is used to heat tissue and thereby destroy a tumor.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* You are eligible to participate in this study if you are an adult (older than 18 years) * Diagnosed with renal cell cancer 1-3 centimeters in size on the CT scan.

Exclusion criteria

* You are not eligible to participate in this study if you are immune compromised (chemotherapy,corticosteroid use, HIV \[as documented in your medical record\], etc.) * Have an autoimmune disorders (Rheumatoid arthritis, Crohn's disease, etc) * Have a tumor larger than 4 cm * Are pregnant.

Design outcomes

Primary

Measure	Time frame	Description
Immune Response to Cryoablation, RFA and Laparoscopic Partial Nephrectomy	4 years	The number of leukocytes found in the tissues cryoablation, radiofrequency ablation, or laparoscopic partial nephrectomy (control)

Outcome results