Obesity and Metabolic Syndrome
Conditions
Keywords
High intensity interval training, Inflammation, Obesity, adipokines
Brief summary
The main purpose of this study is to compare the effects of high intensity interval training and moderate intensity continuous training on inflammatory profile and metabolic markers, after 8 weeks of intervention trial in obese women.
Interventions
OTHERCTR
no counseling or nutritional therapy and no exercise
OTHERMICT
no counseling or nutritional therapy. 8 weeks of individualized and supervised ergometer-based moderate continuous intensity training (MICT).
OTHERHIIT
no counseling or nutritional therapy. 8 weeks of individualized and supervised ergometer-based high intensity interval training (HIIT)
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking)
Intervention model description
Three-arm parallel, Randomized-controlled study
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 41 Years
Healthy volunteers
No
Inclusion criteria
* Body Mass Index between (30-40 kg/m²) * age between 25 and 41 years * to be sedentary
Exclusion criteria
* type 1 or type 2 diabetes * Hypertension * pregnancy, Lactation * having undergone bariatric surgery * psychological disorders, epilepsy, sever neurological disorders * participation in other moderate, vigorous exercise or nutrition intervention * acute or chronic cardiovascular disease * malignant disease * kidney disease * lung disease * hyperthyroidism or hypothyroidism * smoking any type of cigarette * joint limitations * electronic implants (defibrillator, pacemaker)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory profile | 8 weeks (baseline to 8 week follow-up assessment) | C-reactive protein (CRP) (mg/dL) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 8 weeks (baseline to 8 week follow-up assessment) ] | Insulin sensitivity was estimated using homeostasis model assessment index (HOMA) |
| Lipid profile | 8 weeks (baseline to 8 week follow-up assessment) ] | Lipid profile was assessed by measuring levels of triglyceride (TG) (mg/dL), total cholesterol (CT) (mg/dL), high-density lipoprotein cholesterol (HDL-C) (mg/dL) and low-density lipoprotein cholesterol (LDL-C) (mg/dL) |
| Cardiorespiratory Fitness (CRF) | 8 weeks (baseline to 8 week follow-up assessment) ] | CRF was assessed by measuring Peak Oxygen uptake (VO2peak) mL/kg/min |
| Body Composition and Anthropometric profile | 8 weeks (baseline to 8 week follow-up assessment) ] | Body weight (kg), Fat free mass (FFM) (kg), fat mass (FM) (kg) |
| Resting Energy Expenditure (REE) | 8 weeks (baseline to 8 week follow-up assessment) ] | Resting Energy Expenditure (kcal/day) was measured through indirect calorimetry with an open-circuit ventilated-hood system Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min) |
| Substrate oxidation rate | 8 weeks (baseline to 8 week follow-up assessment) ] | Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min) |
| Blood Pressure (BP) | 8 weeks (baseline to 8 week follow-up assessment) ] | Blood Pressure (mmHg) was assessed by measuring rest levels of Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) |
Outcome results
None listed