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The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients

The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03408834
Enrollment
29
Registered
2018-01-24
Start date
2016-01-02
Completion date
2017-10-02
Last updated
2018-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Laparoscopic Colorectal Surgery

Keywords

NGAL, PVI

Brief summary

This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in renal ischemic injury, was used.

Detailed description

Our object in this study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatine in renal ischemic injury, was used. Patients undergoing elective laparoscopic colorectal surgery, 18 to 75 years old, planned surgery duration longer than 2 hours, were included in this study. Patients were divided into 2 groups with respect to their fluid resuscitation, Group 1: goal directed fluid therapy via PVI monitoring Group 2: conventional fluid resuscitation. Blood samples were drawn from both groups for NGAL measurement before CO2 insufflation (T0), and at 6th(T1) and 12th(T2) hours after CO2 insufflation. At the end of the surgery, sugammadex was given to all patients for reversal of muscular blockade.

Interventions

OTHERpulse variability index

fluid management with pulse variability index or conventional

Sponsors

Ankara University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* laparoscopic surgery * obese patient

Exclusion criteria

* patient refusal * major comorbidity * renal failure * diabetes mellitus

Design outcomes

Primary

MeasureTime frameDescription
Diagnosis of acute kidney injurypostoperative 6 th hourfollowing up diagnosis of acute kidney injury

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026