Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03408457

Enrollment

130

Registered

2018-01-24

Start date

2018-03-14

Completion date

2019-05-14

Last updated

2019-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anti-Bacterial Agents, Antibiotic, Surgical Wound Infection

Keywords

Surgical wound infection, antibiotic concentration, blood level

Brief summary

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

Interventions

PROCEDUREBlood sampling after antibiotic administration

Sampling of 6 x 8 mL (in sum 48 mL) via the central venous line (established for the surgical procedure) until postoperative day 2

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* elective surgery of rectom, esophagus or liver with indication for a central venous catheter * informed consent

Exclusion criteria

* pregnancy * medical emergency * participation in another study

Design outcomes

Primary

Measure	Time frame	Description
Serum concentration of antibiotic	2 days	ug/mL

Secondary

Measure	Time frame	Description
Surgical wound infection	30 days	Incidence

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026